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Product Minireviews

Application Notes

Certificates

Patents

Handouts

Posters

 



Product Minireview

 

MICROBIOLOGY WITH AQUASPARK™

Rapid and accurate identification of microorganisms remains an important challenge in microbiology. Despite all the numerous methods that are available nowadays, a good combination of simplicity, sensitivity and fast response is yet to be met. This problem can be solved by using highly performing chemiluminescent AquaSpark™ probes, as we have described in our latest scientific product minireview. (PDF)


First publication date: September 2018


AquaSpark™ Minireview

PROLUCIFERINS: MULTIPURPOSE DIAGNOSTIC AND IMAGING TOOLS

Rapid and sensitive pathogens detection is of paramount importance in the food and the pharmaceutical industries as well as in the public health system. Bioluminescence offers considerably higher sensitivity in comparison to chromogenic and fluorescence detection methods. In this new product minireview we highlight the general working principles of ProLuciferins (ProLucs), their uses for bioluminescent bacteria detection and other popular applications including the monitoring of cellular signaling pathways. (PDF)


First publication date: April 2018


Proluciferin Minireview

EXPLORING NEW TERRITORIES WITH DIOXETANES CHEMILUMINESCENCE

This minireview highlights the fascinating chemistry of dioxetanes and their exceptional light emission properties. Special attention is given to recent discoveries in the field which changed the game of chemiluminescence. (PDF)


Latest update: April 2018
First publication date: January 2018


Dioxetane Minireview

BIOLUMINESCENT IMAGING USING IMPROVED LUCIFERINS AND MUTANT LUCIFERASES

The review covers basic science of Luciferase enzymes, mechanistic aspects of FLuc bioluminescence, S.A.R of Luciferins and top-notch discoveries in the field. Particular attention is given to the highly promising area of in vivo bioluminescence. (PDF)


Latest update: April 2018
First publication date:September 2017


Luciferin Minireview

MODERN APPLICATIONS OF LUMINOL CHEMILUMINESCENCE

In this product minireview we discuss the basic science of Luminol Chemiluminescence, its applications and the main areas of innovation in the field. (PDF)


Latest update: April 2018
First publication date: June 2017


Luminol Minireview

NICOTINAMIDE RIBOSIDE – TO RECHARGE MITOCHONDRIA

This product microreview focuses on the biosynthesis of nicotinamide riboside (NR) and its biological effects on the NAD+ metabolism. NR appears to be a promising candidate for the treatment of numerous diseases and as a food supplement. (PDF)


First publication date: February 2018


NR Microreview









Application Notes

 

Cultural Response Tests using Chromogenic and Fluorogenic Substrates

Advanced techniques have been developed for the detection and differentiation of bacteria based on chromogenic and fluorogenic enzyme substrates. These sensitive methods have led to improved accuracy and faster detection of bacteria. This Application Note presents general procedures to detect specific bacteria enzymes using BIOSYNTH’s chromogenic or fluorogenic substrates in standard culture media like Nutrient Broth, Mueller-Hinton or Tryptic Soy media. (PDF)


Cultural Response Test

Use of Aldol® substrates with Gram positive bacteria

We are constantly developing our patented ALDOL® substrates; we explore additional applications for this platform and continue to optimize existing protocols. One of our recent findings shows that ALDOL® substrates inhibit the growth of certain Gram positive bacteria. To eliminate the inhibitory effect, we recommend adding a low concentration of Tween® 80 to the growth media for any applications aiming at the differentiation of Gram positive bacteria. (PDF)


Aldol Application Note

Chromogenic and Fluorogenic Substrates for the Detection of Enterococci

Classically, enterococci are detected using kanamycin-aesculin-azide media. Aesculin is hydrolysed by beta-glucosidase to glucose and aesculetin, the latter forms a brown-black coloured compound with ferric ions.
More recently, chromogenic and fluorogenic substrates for identification of Enterococcus spp. were developed, including a substrate for a second characteristic enzyme of these bacteria, pyroglutamyl aminopeptidase (L-Pyroglutamic acid 7-amido-4-methylcoumarin). (PDF)


Chromogenic and Fluorogenic Substrates









Certificates

 


ISO 9001:2008 Biosynth

GMP Certificate

PMDA Inspection Result

ISO 14001-2004 TAU-CHEM

ISO 9001:2008 TAU-CHEM

TAU-CHEM Practical Teaching









Patents

 


Novel Applications of Indoloindole and Indoloquinoline Dyes

Novel Indicator Platform

Novel Mehod for Detection of Beta-D-Glucuronidase









Handouts

 

AquaSpark™ - MAXIMUM LIGHT FOR LIFE SCIENCE APPLICATIONS

Imagine you could spot every important enzyme activity by an immediate light signal... (PDF)


AquaSpark

PROLUCIFERINS FOR MICROBIOLOGY

Biosynth offers a full range of ProLuciferins (or 'caged luciferins'). (PDF)


ProLuciferin

HIGHLY ATTRACTIVE PHEROMONES

Our solutions for biocontrol. For pest monitoring. To preserve the value of wood and crops. (PDF)


Pheromones

Aldol® 515 Phosphate

A powerful chromogenic substrate for the detection of Staphylococcus aureus


Aldol 515 Phosphate Handout

Switch off Bacteria Background

selectively by enzyme-triggered inhibition


Galactozide Handout

New Colors for Microbiologists

Four innovative chromogenic enzyme substrates


New Colors for Microbiologists

viF™ - Fluorescent Dyes and Labels

Bright signals and high chemical stability


viF Flyer

Microbiological Detection of E. Coli

RUG™ - A novel beta-glucuronidase substrate


RUG Handout









Posters

 

beta-D-Galactosidase Substrates

for the detection of E. coli and coliforms


Experts in Chemiluminescence

Coelenterazine, Dioxetanes, Luciferin, Lucigenin, Luminol






Galactozide™

Enzyme-Activated Inhibitor






Fine Chemicals for Clinical and Industrial Microbiology

Diagnostics, Isolation, Identification, Cultivation






Plant Growth Regulators

Auxins, Cytokinins, Giberrellins (GA3), Abscisic Acid (ABA)






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